Tuesday, April 30, 2013

Paidpiper Launches At Disrupt NY, Letting You Pay For Others' Purchases In Stores

okd_homescreenPaidpiper launched at Disrupt NY today, aiming to make your physical wallet, and presence, less necessary -- in a good way. Paidpiper aims to solve that problem with its consumer-facing app, Ok?d. Using Ok?d, you can walk into a store, snap a picture of a product, and send it to a friend, parent, employer, etc. and ask them to pay for it.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/jj6oTWTw7ik/

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Twitter Should Shut Me Down

In August of 2012 I left my job at a startup in New York City. I was 24.

Read more...

    


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/y_BbaZfGp9c/twitter-should-shut-me-down-484175370

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Avalanche fire coach Joe Sacco

DENVER (AP) ? Colorado Avalanche coach Joe Sacco was fired on Sunday after the team missed the playoffs for the third straight season.

The Avs never got on track in the lockout-shortened season and finished last in the Western Conference.

Sacco was in his fourth season in charge of Colorado and wound up with a 130-134-30 mark. He had one year left on his contract.

"The organization believes a change of leadership behind the bench is needed going forward," general manager Greg Sherman said in a release. "Joe has worked for this franchise for eight seasons and he is a dedicated and hard-working coach. We appreciate all he has done and wish him the best in the future."

The Avs will soon begin their search for a replacement.

Sacco spent two seasons in charge of the organization's American Hockey League affiliate squad, the Lake Erie Monsters, before taking over the Avs in 2009 after the firing of Tony Granato.

A former NHL player, Sacco preached a fast-paced style and it served the youthful Avalanche well in his first season as the team earned a postseason spot. He was even a finalist for the NHL's coach of the year.

But Colorado couldn't duplicate that success.

Moments after a 3-1 loss to Minnesota on Saturday to close out the regular season, Sacco was asked about his future, saying, "We're certainly headed in the right direction."

His team was committed to his up-tempo philosophy. Matt Duchene recently said that Sacco's message was still getting across.

"We've all played the system he's put in place to the best of our ability. We've all worked at it," said Duchene, who finished tied with P.A. Parenteau for the team scoring lead with 43 points. "We're all still buying in and working."

Sacco will be back on the bench later this week when he leads the U.S. squad at the world championships. He will even take several Avalanche players with him, including Paul Stastny and Erik Johnson.

Source: http://news.yahoo.com/avalanche-fire-coach-joe-sacco-174513532.html

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How They Filmed Return Of The Jedi's Absurdly Great Speeder Chase

This year marks the 30th anniversary of Return Of The Jedi, the Ewok-filled amazingness that spelled the end of the original Star Wars trilogy. That film contained one of the most amazing high-speed chases ever seen on film. This is how they brought that death-defying chase to life.

One of the highlights of Return Of The Jedi is the speeder chase between the Rebels and the Empire. The Rebels need to distract the Scout Troopers in order to deactivate the shield generator, which would let the Rebel fleet penetrate the Death Star and defeat the Galactic Empire.

But you knew that already.

In the scene, Luke and Leia jump on their speeders and then race through the forest at seriously crazy high speeds. There are tons of narrow misses and there was obviously no way to safely or realistically do this at those high speeds.

That's because it wasn't close to real. The natural assumption is the chase was filmed on a dirtbike and then the footage was sped up, but there's a problem with that: Dirtbikes aren't exactly the smoothest riding vehicles in the world. The speeders float on the air, which means they need to appear smoother than a motorcycle could ever be.

The solution was clever and somewhat old fashioned. Cameras were operated at 3/4 of a frame per second as cameramen walked through Cheatham Grove, CA with steadicams. It sounds like it was back-breaking work:

Just 100 more yards. My left hand is slippery with sweat. Legs tired. Brain hurts most of all. I wonder if really intense concentration produces any lingering harmful effects...look at Bobby Fisher! (At a camera speed of only 3/4 frame per second, a thousand feet of precise walking gets you just 16 feet of VistaVision in the can, and every take you forget a few more important phone numbers, or a family birthday.) Is it worth it? At this rate I will be illiterate in a week and a vegetable in two.

Not only was cameraman Garrett Brown wearing the steadicam, he also had two gyroscopes attached to it for extra stabilization, although a slight amount of wobble was still wanted to make it semi-realistic. He also had to concentrate on the target like a sniper. One misstep would mean a ruined take and another slow trudge through the forest. At 3/4 speed, Brown says that 1,000 feet of walking got him 16 usable feet of footage.

Brown was personally skeptical of the idea when it was presented to him. But instead of saying no, he decided to go for it. What resulted was a cameraman walking slowly through the forest with a ton of equipment, where any slight error would cause him to start over again.

The 3/4 speed footage was sped up 30 times in order to make the film the standard 24 frames per seconds. That also made the speed appear to be a mind-boggling 120 MPH through the forest. Brown had to repeatedly walk through the forest in order to get the right shots. Filming at a slow speed like that also didn't let them calculate for exposure, but it seems that their guesswork was spot on and the corrections done in post production made for a great looking scene.

Was the agony of walking through the forest super slowly and making hundreds of cuts to get a three minute chase worth it? Damn right it was.

Source: http://jalopnik.com/how-they-filmed-return-of-the-jedis-absurdly-great-spe-484407675

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2 police shot outside Italian premier's office

ROME (AP) ? Italy's interior minister says the shooting that seriously wounded two policemen in a square outside the premier's office in Rome was a "tragic criminal gesture by an unemployed man."

A female passer-by was slightly injured in the shooting, which happened just as Premier Enrico Letta and his new government were being sworn in Sunday elsewhere in the city.

Interior Minister Angelino Alfano told reporters the alleged gunman ? Luigi Preiti, a 49-year-old Italian ? wanted to kill himself after the shooting but ran out of bullets. The minister says Preiti fired six shots.

Source: http://news.yahoo.com/2-police-shot-outside-italian-premiers-office-115304512.html

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Monday, April 29, 2013

Opry to hold public funeral for George Jones

NASHVILLE, Tenn. (AP) ? A public funeral will be held at the Grand Ole Opry House in Nashville for country music superstar George Jones, who died Friday at the age of 81.

Publicist Kirt Webster said in a statement that the public funeral will be held Thursday starting at 10 a.m. Webster says Jones would have wanted his fans everywhere to be able to pay their respects along with his family.

A private visitation for family, friends and fellow performers will take place Wednesday evening. In lieu of flowers, the family is asking that contributions be made to the Grand Ole Opry trust fund or the Country Music Hall of Fame and Museum.

Source: http://news.yahoo.com/opry-hold-public-funeral-george-jones-223242295.html

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Even Vinny Magalhaes can?t believe a judge gave him a round in UFC 159 loss to Phil Davis

At UFC 159 on Saturday night, Phil Davis showed off the best striking of his career. The NCAA Division-I champion wrestler clearly dominated Vinny Magalhaes in all three rounds on the way to a unanimous decision win. However, one of the judges thought Magalhaes won one round, and the score was 30-27, 30-27, 29-28.

It was a surprising score. It didn't take anything away from Davis' win, but it was odd enough that Magalhaes spoke up about it.

Davis and Magalhaes talked trash to each other for months before their bout. Magalhaes left the bad blood in the cage, and was able to give himself an honest assessment moments after the loss.

Source: http://sports.yahoo.com/blogs/mma-cagewriter/even-vinny-magalhaes-t-believe-judge-gave-him-034024125.html

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Should Game Makers Worry About the Shift to Non-Gaming - Benzinga

In 2012, Yusuf Mehdi -- the man in charge of Microsoft's (NASDAQ: MSFT) interactive entertainment business -- told the Los Angeles Times that the average Xbox-owning household spends an average of 84 hours a month using Xbox Live.

While gaming continues to be a popular draw for the console, it has not become the primary reason why people turn it on.

"What we're seeing is that people are turning on the Xbox to play games and then keeping it on afterwards to get other types of entertainment," Mehdi told the Los Angeles Times.

In fact, the publication reported that consumers now spend more of their time using Xbox 360 for online video than for online gaming.

There have not been any studies confirming that the same has happened with Wii or PlayStation 3, but Sony (NYSE: SNE) proudly announced that its console had become the number-one living room device for Netflix (NASDAQ: NFLX) subscribers last December.

The console has been so successful in this regard that there have been times when more people turned to PS3 for Netflix than for any other platform -- including PCs and tablets.

In April, NPD DisplaySearch reported that game consoles lead the pack among TV devices that can connect to the Internet.

This is great for overall hardware appeal -- but is it good for the gaming industry?

Mehdi's statement seems to be fairly accurate. Game consoles have always been sold first to consumers who want to play games. If they only cared about non-interactive entertainment, consumers would simply subscribe to cable or buy a set-top box.

By offering a greater variety of entertainment options, the assumption is that consoles can appeal to a greater number of consumers. This is also true -- but it is not without risk.

When Sony unveiled PlayStation 4, it chose to ignore non-gaming entertainment and focus exclusively on why this is a console that gamers should buy.

In an interview with Forbes, Sony Computer Entertainment America President and CEO Jack Tretton explained why.

"If you wanna have an event to talk about multimedia capabilities, we'll proudly stand up and list all the media partners that we have, and the fact that we're the number one most used Netflix device around the world," said Tretton. "But the 3.1 million that streamed [Wednesday's event] and that stayed up at all hours depending on what country they were in, they were there to see games."

The 3.1 million viewers that he referred to were only in the United States. Worldwide, Sony's event drew more than eight million viewers.

This is the same strategy that Sony took with PSone (which sold 104 million units) and PS2 (which sold 153 million units).

When promoting PlayStation 3, Sony shifted to other things. While gaming was still a big part of the console, Sony heavily pushed the Blu-ray player that was built into every unit.

As many investors are aware, PS3 only sold 74 million units.

Similarly, Nintendo (OTC: NTDOY) tried to make up for the lack of new Wii U games by promoting a number of promising TV services. While the console sold very well last fall, Wii U ultimately flopped during the first quarter when sales plummeted more than 85 percent.

Thus, while it is acceptable (and perhaps wise) for console manufacturers to offer services beyond video games, it is best to start by satisfying the core gaming audience. If nothing else, that guarantees that at least some people will buy the device.

If the aforementioned trend continues, however -- if games are the initial draw but TV and movies keep users coming back -- it could be a problem for those who only develop games.

Activision (NASDAQ: ATVI), Electronic Arts (NASDAQ: EA), Konami (NYSE: KNM), Take-Two Interactive (NASDAQ: TTWO) and other game companies heavily rely on the success of new consoles.

Sony, Microsoft and Nintendo may get consumers in the door, but if the aforementioned developers can't keep them coming back, the industry is in trouble.

Over the past 10 years, several high-profile game publishers have fallen, including THQ, Acclaim and Midway. While it does not appear that another one is about to file for bankruptcy, there is one whose future is in question: Electronic Arts.

Between the troubled launch of the new Sim City, the closure of several Facebook (NASDAQ: FB) games, the award for 'Worst Company in America' (for the second year in a row), and the widespread layoffs, things are not looking good for EA.

Louis Bedigian is the Senior Tech Analyst and Features Writer of Benzinga. You can reach him at 248-636-1322 or louis(at)benzingapro(dot)com. Follow him @LouisBedigianBZ

Source: http://www.benzinga.com/tech/13/04/3535563/should-game-makers-worry-about-the-shift-to-non-gaming-entertainment

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The Party Of Morning Joe (Atlantic Politics Channel)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, News Feeds and News via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/302178456?client_source=feed&format=rss

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Sunday, April 28, 2013

Gunshots fired near Italy prime minister's office; injuries reported

* Lewandowski scored four goals against Real Madrid * Poland international refuses contract extension (adds details, background) BERLIN, April 26 (Reuters) - Bayern Munich and Borussia Dortmund striker Robert Lewandowski have not signed a deal, the newly-crowned champions said on Friday, shooting down widespread speculation of another imminent surprise transfer. "Bayern, as opposed to some reports, has no contract with Robert Lewandowski," the Bavarian Champions League semi-finalists said in a brief statement. ...

Source: http://news.yahoo.com/gunshots-fired-near-italy-prime-ministers-office-injuries-094502095.html

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Boosting the powers of genomic science

Friday, April 26, 2013

As scientists probe and parse the genetic bases of what makes a human a human (or one human different from another), and vigorously push for greater use of whole genome sequencing, they find themselves increasingly threatened by the unthinkable: Too much data to make full sense of.

In a pair of papers published in the April 25, 2013 issue of PLOS Genetics, two diverse teams of scientists, both headed by researchers at the University of California, San Diego School of Medicine, describe novel statistical models that more broadly and deeply identify associations between bits of sequenced DNA called single nucleotide polymorphisms or SNPs and say lead to a more complete and accurate understanding of the genetic underpinnings of many diseases and how best to treat them.

"It's increasingly evident that highly heritable diseases and traits are influenced by a large number of genetic variants in different parts of the genome, each with small effects," said Anders M. Dale, PhD, a professor in the departments of Radiology, Neurosciences and Psychiatry at the UC San Diego School of Medicine. "Unfortunately, it's also increasingly evident that existing statistical methods, like genome-wide association studies (GWAS) that look for associations between SNPs and diseases, are severely underpowered and can't adequately incorporate all of this new, exciting and exceedingly rich data."

Dale cited, for example, a recent study published in Nature Genetics in which researchers used traditional GWAS to raise the number of SNPs associated with primary sclerosing cholangitis from four to 16. The scientists then applied the new statistical methods to identify 33 additional SNPs, more than tripling the number of genome locations associated with the life-threatening liver disease.

Generally speaking, the new methods boost researchers' analytical powers by incorporating a priori or prior knowledge about the function of SNPs with their pleiotrophic relationships to multiple phenotypes. Pleiotrophy occurs when one gene influences multiple sets of observed traits or phenotypes.

Dale and colleagues believe the new methods could lead to a paradigm shift in CWAS analysis, with profound implications across a broad range of complex traits and disorders.

"There is ever-greater emphasis being placed on expensive whole genome sequencing efforts," he said, "but as the science advances, the challenges become larger. The needle in the haystack of traditional GWAS involves searching through about one million SNPs. This will increase 10- to 100-fold, to about 3 billion positions. We think these new methodologies allow us to more completely exploit our resources, to extract the most information possible, which we think has important implications for gene discovery, drug development and more accurately assessing a person's overall genetic risk of developing a certain disease."

"All SNPs are not created equal: Genome-wide association studies reveal a consisten pattern of enrichment among functionally annotated SNPs." Authors include Andrew J. Schork, UCSD Cognitive Sciences Graduate Program, UCSD Center for Human Development and UCSD Multimodal Imaging Laboratory; Wesley K. Thompson and John R. Kelsoe, Department of Psychiatry, UCSD; Phillip Pham, Scripps Health, The Scripps Research Institute (TSRI); Ali Torkamani and Nicholas J. Schork, Scripps Health, TSRI; J. Cooper Roddy, UCSD Multimodal Laboratory; Patrick F. Sullivan, University of North Carolina; Michael C. O'Donovan, Cardiff University, United Kingdom; Helena Furberg, Memorial Sloan Kettering Cancer Center; The Tobacco and Genetics Consortium, The Bipolar Disorder Psychiatric Genomics Consortium, The Schizophrenic Psychiatric Genomics Consortium; and Ole A. Andreassen, UCSD Department of Psychiatry, University of Oslo and Oslo University Hospital.

"Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional False Discovery Rate."

###

University of California - San Diego: http://www.ucsd.edu

Thanks to University of California - San Diego for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/127968/Boosting_the_powers_of_genomic_science

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Dr. Scott D. Miller: What's Changed -- and Hasn't -- in the Coverage of Breaking News

Media coverage of the tragic and ongoing developments related to the Boston Marathon bombings highlights the dramatic changes in breaking-news coverage as the nation prepares to mark the 50th anniversary of another horrifying tragedy in our history -- the 1963 assassination of President John F. Kennedy. Much has changed, and much has not, since that grim day in Dealey Plaza. In any case, as has been true for some time now, the implications for communications students at our nation's colleges and universities are significant.

The death of JFK, who once spoke on the Bethany College campus, was a watershed event in instant, breaking-news coverage. After initial voiceover bulletins announcing gunshots in the president's motorcade (Walter Cronkite of CBS broke in on the soap opera As the World Turns) on Friday, November 22, all three networks and some local stations went live with continual, on-the-air studio updates of the unfolding events in Dallas. Coverage would last all the way through Kennedy's funeral on that Monday. Memorably, Cronkite fought for composure as he announced on the air the "apparently official" death of the young president whom he had personally interviewed for a CBS special a little more than two months before.

"Uncle Walter," like most of his broadcast contemporaries, had come to the TV newsroom from conventional journalism (newspaper) backgrounds. Fifty years ago, in 1963, the media landscape was still dominated by the printed word, and by the imperative of getting the story right before it was published in early and final editions of America's newspapers. Indeed, Americans still received their daily news from the newsprint page -- cities had several morning and afternoon papers -- and from abbreviated nightly TV broadcasts by three major networks (CBS, NBC, and ABC) featuring trusted male-authority figures, like Cronkite, Chet Huntley, David Brinkley and others. There were limited visuals. Videotape and live, remote news coverage were in their infancy. Not every TV program was broadcast in color. The idea of 24-hour-a-day news broadcasting later pioneered by CNN, or a channel devoted exclusively to weather coverage, would have seemed then like science fiction.

Radio was terrestrial, often featuring live, original programming in contrast to today's digital, recorded formats. We had barely begun the age of human space flight, let alone launched the kinds of sophisticated, orbital satellites that now permit instant, global transmission of sight and sound. Online news sources and advertising, the hundreds of cable TV options we now have, webstreaming, and other media developments familiar to us today were decades away.

Film and still photography, not TV trucks with antennae positioned for satellite downloads, recorded the fatal shots in Dallas. Wire-service reporters initially called in the story.

Two days after the president's assassination, another shooting was captured live on TV with the stunning murder of the president's accused assassin, Lee Harvey Oswald. Television news was no longer studio-bound, but instead a live witness to history -- and in the minds of many, that weekend changed broadcasting media forever.

Fast-forward to the events in Boston of April 15. This time, the tragedy was covered from multiple angles; everyone with a cell phone was a potential witness. Indeed, digital photography, video and social media were instrumental in the tracking, days later, of the bombing suspects and the placing in custody of the surviving one. Daily coverage of the aftermath of the Boston Marathon bombings, including the climactic manhunt in Watertown, continues. Four heartbreaking days in November 1963, in which the media were largely observers -- influential ones, yes, but in a much more limited role compared to today -- have been supplanted by instant, 24-hour coverage, commentary, opinion, speculation.

As with Dallas in 1963, much of the early reported information from the site of the Marathon was simply inaccurate. But today's media, with their blurring of the roles of reporter and commentator, with the on-air personalities becoming more and more a part of the story itself, with live TV and social media facilitating not just coverage but a national conversation about the story, make Walter Cronkite's suppressed emotion on November 22, 1963, seem like a model of restraint and dignity.

Further, what may have taken a generation for a photo to be considered "iconic" can now receive that designation in moments -- especially if it has a connotation of the events of 9/11 and the raw, vulnerable feelings of Americans, accompanied by scenes of instant, makeshift memorials, fist-pumping patriotism, the raising of a recovered American flag over Ground Zero.

Technology has ramped up the immediacy of any breaking news, and we expect that -- indeed, depend on it. Yet the lessons for students of what used to be known as journalism lead to longstanding, critical questions about whether we still require "getting it right" before going with the details of any story; what the limits should be, if any, in reporting on the workings of law enforcement (Oswald was surrounded by cameras and reporters when he was gunned down in the Dallas police headquarters; NBC's Lester Holt in Boston revealed to viewers that a police officer had yelled at him for venturing too close to barricades); what privacy victims' families deserve versus their own increasing, expected and highly visible roles in the public's hunt for justice; whether all the instant, constant coverage will continue to desensitize us not only to the horror of such tragedies but also to the agenda of prevention of terrorism and the preservation of social order. Most who lived through Kennedy's assassination were probably never quite the same afterward. Boston, admittedly a different kind of calamity, is the latest in a series. The media this time were quick to pounce with commentary on the supposed "complacency" of our nation in the intervening years since September 11, 2001.

Perhaps most compelling of all is the question of whether online and social media can, or should, ever be restrained or controlled. The accused Boston bombers reportedly learned their craft on the Internet; their demise was at the hands of dedicated, heroic police officers and a band of Big Brothers with mobile phones.

It's a conversation students and faculty should have as we brace ourselves for what might come next and which will, inevitably, not simply unfold as a story but explode.

Stand by....

Dr. Scott D. Miller is president of Bethany College and M.M. Cochran Professor of Leadership Studies. Now in his 22nd year as a college president, he serves as a consultant to college presidents and boards.

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Follow Dr. Scott D. Miller on Twitter: www.twitter.com/BethanyCollege1

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Source: http://www.huffingtonpost.com/dr-scott-d-miller/whats-changedand-hasntin-_b_3164516.html

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PFT: Jets deal fourth-rounder for Saints RB Ivory

Manti Te'oAP

Here are the terms of trades completed on Friday, April 26, the second day of the 2013 NFL Draft. All draft picks are 2013 selections unless otherwise noted:

The Titans acquired a second-round pick from San Francisco (No. 34 overall), sending second- and seventh-round picks (Nos. 40, 216) in 2013 and a 2014 third-rounder to the 49ers. The Titans selected Tennessee wide receiver Justin Hunter at No. 34. The 49ers took Florida State defensive lineman Cornellius ?Tank? Carradine at No. 40.

The Chargers traded for the Cardinals? second-round pick (No. 38), giving up second- and fourth-round picks (Nos. 45, 110) to Arizona. The Chargers used selection No. 38 on Notre Dame linebacker Manti Te?o, while the Cardinals took LSU linebacker Kevin Minter at No. 45.

The 49ers acquired the Packers? second-round pick (No. 55). In return, San Francisco surrendered second- and sixth-round picks (Nos. 61, 173). The 49ers took Rice tight end Vance McDonald at No. 55. The Packers used the No. 61 choice on Alabama running back Eddie Lacy.

The Ravens traded for the Seahawks? second-round selection (No. 56). Baltimore sent Seattle second-, fifth- and sixth-round picks (Nos. 62, 165, 199) to complete the deal. The Ravens took Kansas State linebacker Arthur Brown with pick No. 56. Six picks later, the Seahawks selected Texas A&M running back Christine Michael at No. 62.

The Saints acquired a third-round selection from Miami (No. 82). In exchange, the Dolphins received two fourth-round picks (Nos. 106, 109) from New Orleans. The Saints took Georgia nose tackle John Jenkins at No. 82. The Dolphins would trade selection No. 109 to Green Bay.

The 49ers traded for the Packers? third-round choice (No. 88), surrendering third- and seventh-round picks (Nos. 93, 216) to Green Bay. With pick No. 88, San Francisco chose Auburn defensive lineman Corey Lemonier. The Packers would deal the 93rd selection to Miami (see next entry).

The Dolphins acquired a third-round pick from Green Bay (No. 93), giving up fourth-, fifth- and seventh-round picks (Nos. 109, 146, 224). The Dolphins selected Utah State cornerback Will Davis at No. 93.

The Dolphins traded wide receiver Davone Bess and their fourth- and seventh-round picks (Nos. 111, 217) to Cleveland. In return, the Browns sent the Dolphins fourth- and fifth-round picks (Nos. 104, 164).

The Saints traded running back Chris Ivory to the Jets in exchange for New York?s fourth-round pick (No. 106). The Saints dealt No. 106 in a package for pick No. 82, which was used on Georgia nose tackle John Jenkins.

Source: http://profootballtalk.nbcsports.com/2013/04/26/jets-trade-fourth-to-saints-for-chris-ivory/related/

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Wash. judge tells police to return marijuana

TACOMA, Wash. (AP) ? Police in Tacoma could soon be in real trouble over pot.

The department could be found in contempt if they continue to refuse to return a small amount of marijuana seized from a man after a traffic stop. Municipal Court Judge Jack Emery repeated an order to police Thursday to return the drug to Joseph L. Robertson within seven days or they could be found in contempt.

"Appeal or comply," Emery told assistant city attorney John Walker. "Or next week, show up, and I would advise you to bring counsel."

The judge first ordered police to return the drug on Feb. 28, but they have refused, The News Tribune reported Friday (http://bit.ly/10hwiD9 ).

It was seized in May of last year when an officer pulled over the Tacoma man for speeding. He was cited for driving without a license and misdemeanor marijuana possession. Prosecutors dismissed the drug charge in December, after state voters decided to legalize small amounts of the drug.

Robertson then asked for his pot back, and provided proof of medical marijuana authorization. The city refused, which led to Emery's Feb. 28 order. If the matter is not settled by the May 2 hearing, it could go to higher courts.

The pot is now in the possession of the Pierce County sheriff's department, which operates the property room for seized evidence. Deputies won't give it to Robertson.

"It's Tacoma's case," said sheriff's spokesman Ed Troyer. "If they want it, they can come and get it."

Although the judge said he thinks "there's contemptuous behavior here," Emery added that the case was "a quagmire," due to the conflicting provisions of state and federal law.

___

Information from: The News Tribune, http://www.thenewstribune.com

Source: http://news.yahoo.com/wash-judge-tells-police-return-marijuana-175510368.html

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Saturday, April 27, 2013

Israel fears end to 40-year peace on Syrian front

In this photo taken Wednesday, April 24, 2013, Gal Hirsch, a reserve Israeli General, stands at an army outpost overlooking Syria and Jordan in the Golan Heights. Against a breathtaking vista of green fields and a snowcapped mountain range, all is silent but for a strong gust of wind whipping across the landscape. The tranquility is suddenly interrupted by a burst of gunfire from beyond a newly built fortified fence: Jihadi rebels are battling with Bashar Assad's battered troops in a nearby Syrian village. Watching it all unfold are Israeli soldiers atop tanks - a sight unseen here in a generation - and the sounds of explosions from a large-scale Israeli drill are distinctly heard in the background. (AP Photo/Sebastian Scheiner)

In this photo taken Wednesday, April 24, 2013, Gal Hirsch, a reserve Israeli General, stands at an army outpost overlooking Syria and Jordan in the Golan Heights. Against a breathtaking vista of green fields and a snowcapped mountain range, all is silent but for a strong gust of wind whipping across the landscape. The tranquility is suddenly interrupted by a burst of gunfire from beyond a newly built fortified fence: Jihadi rebels are battling with Bashar Assad's battered troops in a nearby Syrian village. Watching it all unfold are Israeli soldiers atop tanks - a sight unseen here in a generation - and the sounds of explosions from a large-scale Israeli drill are distinctly heard in the background. (AP Photo/Sebastian Scheiner)

In this photo taken Wednesday, April 24, 2013, a worker builds a security fence along the border between Israel and Syrian on the Golan Heights. Against a breathtaking vista of green fields and a snowcapped mountain range, all is silent but for a strong gust of wind whipping across the landscape. The tranquility is suddenly interrupted by a burst of gunfire from beyond a newly built fortified fence: Jihadi rebels are battling with Bashar Assad's battered troops in a nearby Syrian village. Watching it all unfold are Israeli soldiers atop tanks - a sight unseen here in a generation - and the sounds of explosions from a large-scale Israeli drill are distinctly heard in the background. (AP Photo/Sebastian Scheiner)

In this photo taken Wednesday, April 24, 2013, an Israeli soldier looks through binoculars at a Syrian village from an army post on the border between Israel and Syrian on the Golan Heights. Against a breathtaking vista of green fields and a snowcapped mountain range, all is silent but for a strong gust of wind whipping across the landscape. The tranquility is suddenly interrupted by a burst of gunfire from beyond a newly built fortified fence: Jihadi rebels are battling with Bashar Assad's battered troops in a nearby Syrian village. Watching it all unfold are Israeli soldiers atop tanks - a sight unseen here in a generation - and the sounds of explosions from a large-scale Israeli drill are distinctly heard in the background. (AP Photo/Sebastian Scheiner)

In this photo taken Wednesday, April 24, 2013, Israeli soldiers stand next to a metal placard in the shape of an Israeli soldier, at an observation point on Mt. Bental in the Golan Heights, Against a breathtaking vista of green fields and a snowcapped mountain range, all is silent but for a strong gust of wind whipping across the landscape. The tranquility is suddenly interrupted by a burst of gunfire from beyond a newly built fortified fence: Jihadi rebels are battling with Bashar Assad's battered troops in a nearby Syrian village. Watching it all unfold are Israeli soldiers atop tanks - a sight unseen here in a generation - and the sounds of explosions from a large-scale Israeli drill are distinctly heard in the background. (AP Photo/Sebastian Scheiner)

(AP) ? Against a vista of green fields and snowcapped mountains, all is silent but for a gusting wind. Then comes a burst of gunfire from the Syrian civil war raging next door, where jihadist rebels are battling Bashar Assad's troops in a village.

Watching it all unfold from a few kilometers (miles) away are Israeli soldiers atop tanks behind a newly fortified fence, while a large-scale Israeli drill sends off its own explosions in the background.

This is the new reality on the Israeli-occupied Golan Heights, for 40 years the quietest of Israel's front lines, a place of hiking trails, bird-watching, skiing and winery tour. The military predicts all that will soon change as it prepares for the worst ? a power vacuum in Syria in which rogue groups could get their hands of the country's large stockpile of chemical weapons.

In many ways, a new era has already begun. The Syrian villages along the border change hands between military and rebel strongholds in daily battles. Their mortar shells and bullets frequently land on the Israeli side, including in some cases narrowly missing soldiers and civilians. A Syrian army tank shell landed in the border community of Alonei Habashan in February.

Though Israel believes these have mostly been cases of errant fire, it has responded with firepower of its own on several occasions in the first round of hostilities since a long-term armistice took hold after the 1973 Mideast war.

"This area became a huge ungoverned area and inside an ungoverned area many, many players want to be inside and want to play their own role and to work for their own interests," said Gal Hirsch, a reserve Israeli brigadier general who is involved in the military's strategic planning and operations. "Syria became a place that we see as a big threat to Israel and that is why we started to work in the last two years on a strong obstacle, on our infrastructure, in order to make sure that we will be ready for the future. And the future is here already."

Officials say the military's present deployment on the plateau is its most robust since 1973, and its most obvious manifestation is the brand new border fence, 6 meters (20 feet) tall, topped with barbed wire and bristling with sophisticated anti-infiltration devices. The previous rundown fence was largely untested until it was trampled over last year by Syrians protesting on behalf of Palestinians.

The military would not detail other measures it is taking, but stressed it was actively defining the new border arrangement now, before it could be too late.

On the other side of the frontier, the village of Bir Ajam is in rebel hands and Israeli troops report watching them successfully deflect Syrian military pre-dawn raids almost daily. In a village nearby, Syrian intelligence and commando forces are based in concrete, windowless structures.

At the triangle where the borders of Israel, Syria and Jordan meet along the Yarmouk River, a lone jeep is seen crossing uninterrupted from Jordan into Syria. In March, rebels kidnapped 21 Filipino U.N peacekeepers nearby. Thousands of refugees have used the route to flee the carnage into Jordan.

A few injured refugees have trickled into the Golan, and the military runs a field clinic to treat them. But there's no guarantee the trickle won't become a flood if Jordan in the south or Turkey in the north become unreachable.

"Syria right now is a kind of self-evolving system," Hirsch said. "No one can control or predict everything."

Israel, which borders southwestern Syria, has thus far been careful to stay on the sidelines of a civil war that has already claimed the lives of more than 70,000.

Assad is a bitter enemy, an ally of Iran and a major backer of Lebanese Hezbollah guerilla attacks against Israel. But like his father whom he succeeded as president, he has faithfully observed U.S.-brokered accords that ended the 1973 war. Israel worries that whoever comes out on top in the civil war will be a much more dangerous adversary.

Chief among Israeli concerns is that Assad's advanced weaponry could reach the hands of either his ally, the Hezbollah militant group in Lebanon, or Islamic extremist groups among the rebels trying to oust him.

"Syria is not a regular place ... it is the biggest warehouse for weapons on earth," Hirsch warned.

In an interview with BBC TV last week, Prime Minister Benjamin Netanyahu called the rebel groups among "the worst Islamist radicals in the world."

"So obviously we are concerned that weapons that are ground-breaking, that can change the balance of power in the Middle East, would fall into the hands of these terrorists," he said.

This week, a senior Israeli military intelligence official said Assad used chemical weapons last month. After initial denials, American and British officials confirmed the assessment of Brig. Gen. Itai Brun, the head of research and analysis in Israeli military intelligence, that the lethal nerve agent sarin was probably used. U.S. President Barack Obama has warned that the introduction of chemical weapons by Assad would be a "game changer" that could usher in greater foreign intervention in the civil war.

For Israel, the specter of peace with Syria disintegrating adds to a growing sense of siege. It saw the Gaza Strip fall to the militant Hamas movement in an election in 2006. And Egypt, the most populous Arab country and the first to make peace with Israel, is now ruled by the fiercely anti-Israeli Muslim Brotherhood. All this against the backdrop of the Iranian nuclear program and its threats to destroy the Jewish state.

Israel has all but admitted that its warplanes destroyed a shipment of anti-aircraft missiles believed to be headed from Syria to Hezbollah in Lebanon in January, and on Thursday it shot down a drone which it said it suspects was operated by Hezbollah. Hezbollah denied launching it.

Hirsch, who commanded an Israeli division in a monthlong war with Hezbollah in 2006, said war regional roles have since then been reversed. While once Syria used Hezbollah in Lebanon as a proxy against Israel, Hezbollah is now deterred from acting on Lebanese soil for fear of Israeli retribution and is preparing to use the instability in Syria as its future staging ground.

"The fighting in Syria gives them an opportunity to open a new front against Israel," said Hirsch. "We must be ready for turbulence. We must be ready for the Iranian involvement inside Syria. We must be ready to be able to fight against radical fundamentalist activities that will come from Syria, and that is what we are doing here."

___

Follow Heller on Twitter (at)aronhellerap

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-04-26-Israel-On%20Syria's%20Doorstep/id-cdaa5de61c694d4a960e6cafe8b54aba

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The Best 3D Printed Objects, A Giant Mars Penis, The Samsung Galaxy S4 Review, And More

Well folks, you have officially made it to the freakin' weekend. And baby, it's about time you had you some fun. To get you started we've got giant Mars penises, an explainer on computers from the 90s, prison cells designed by prisoners, the new Google.com(?), and more. Check it all out below. More »
    


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White House hedges on 'red line'

President Barack Obama during his meeting Friday with King Abdullah II of Jordan. (Pablo Martinez Monsivais/AP???A whole bunch,? meet ?systematic.? President Barack Obama's cautious stance on the conflict in Syria shone clearly Friday as he warned President Bashar Assad that ?the systematic use? of chemical weapons against Syrian rebels would trigger a forceful American response.

Back in August, Obama bluntly warned Assad?s regime that while he had not ?at this point? ordered an American military response to Syria's civil war, ?a red line for us is we start seeing a whole bunch of chemical weapons moving around or being utilized."

When it comes to chemical weapons, what is "a whole bunch"? What does "systematic" mean? The White House has carefully refused to define either term precisely, keeping the president's options open. Republicans have called for a far more forceful U.S. role in Syria, notably by arming the rebels and establishing "safe zones" to protect the opposition or Syrians fleeing the fighting.

In 2008, Obama used his opposition to the Iraq war?and Hillary Clinton?s initial support for it?as a potent weapon to capture the Democratic presidential nomination. The flawed case for toppling Saddam Hussein looms large now as the president wrestles with the U.S. response to signs that Assad?s iron-fisted regime used chemical weapons in Syria?s two-year civil war. The conflict has claimed the lives of an estimated 70,000 people.

?I think all of us, not just in the United States but around the world, recognize how we cannot stand by and permit the systematic use of weapons like chemical weapons on civilian populations,? Obama said as he met Friday in the Oval Office with King Abdullah II of Jordan.

The president?s comments came a day after Defense Secretary Chuck Hagel and the White House revealed that U.S. intelligence believed Assad had used chemical weapons, specifically the deadly nerve agent sarin, against opposition forces in the country's ongoing civil war.

On Thursday, the White House disclosed that "our intelligence community does assess with varying degrees of confidence" that Assad's regime had used sarin. But top officials?from Hagel on down?warned that those findings did not mean that Assad had now crossed Obama's "red line" or that American military action might be imminent. Instead, they said Washington will now work with its allies, Syria's opposition and the United Nations to build what one top Obama aide called an ?airtight? case.

"These are preliminary assessments; they?re based on our intelligence gathering. We have varying degrees of confidence about the actual use, but there are a range of questions around how, when, where these weapons may have been used," Obama said Friday, vowing "to make sure that we are investigating this as effectively and as quickly as we can."

"But I meant what I?d said, and I will repeat," he said. "Horrific as it is when mortars are being fired on civilians and people are being indiscriminately killed, to use potential weapons of mass destruction on civilian populations crosses another line with respect to international norms and international law. And that is going to be a game changer."

"We have to act prudently. We have to make these assessments deliberately. But I think all of us, not just in the United States but around the world, recognize how we cannot stand by and permit the systematic use of weapons like chemical weapons on civilian populations," he said.

Just how big a factor is the March 2003 invasion of Iraq? A senior Obama aide, briefing reporters Thursday on a conference call arranged by the White House, made repeated references to it as a reason to tread cautiously.

?I?d say that given our own history with intelligence assessments, including intelligence assessments related to weapons of mass destruction, it?s very important that we are able to establish this with certainty and that we are able to present information that is airtight in a public and credible fashion," he said. "That is, I think, the threshold that is demanded."

White House press secretary Jay Carney sharply rejected any notion that Obama might show more "leniency" on weapons of mass destruction because of the Iraq War. "Absolutely not," he told reporters at his Friday briefing.

"The fact is that we do have some evidence and we need to build on that," Carney said. "The precedent you cite I think is a significant one, and it simply stands to reason that the assessments that we make, the intelligence community makes, are extraordinarily valuable and they do excellent work, but they are building blocks towards a broader objective here, which is the accumulation of concrete evidence?evidence that can be corroborated, evidence that can be presented and reviewed and then acted on if the conclusion is that a red line has been crossed."

Source: http://news.yahoo.com/blogs/ticket/iraq-looms-large-wary-obama-warns-syria-over-201513845.html

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More Google Glass Specs Revealed As Android Tinkerers Look For Ways To Root It

glasscloseupGoogle felt it appropriate to highlight some of Glass' specs earlier this week, but there's much more to the company's wearable display than just the 5 megapixel camera and its 16GB of internal storage. In case you were hankering for a taste of what else makes Google Glass tick, Android developer (and Glass Explorer) Jay Lee spent some time tinkering with his preview unit and managed to figure out what kind of hardware it has under the proverbial hood.

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Blink, A New App For Ephemeral Text And Photo Messaging, Arrives On iPhone

Blink-LogoBlink, a new mobile application for ephemeral messaging, is debuting today on the Apple App Store allowing users to text, plus share photos, and soon videos, with other friends as well as with groups. The app represents?a spin-off from the same technology which also powers social friend finder, Kismet. Though the company says it has no plans to shut down Kismet at this time, its current focus will be on continuing the development of Blink at present. You may remember Kismet, founded by ex-Googler Kevin Stephens and Michelle Norgan, as one of the apps which surged in popularity around the time of SXSW 2012, when “ambient location” seemed to be the latest trend. As it turned out, while Kismet saw some pick up on college campuses, and particularly in the Greek community, its user base remained under a million. Now Blink is repurposing the company’s technology platform to attack mobile social networking from a new angle: disposable messaging. The mobile messaging market is huge, fragmented, and growing, but competitors focused on ephemeral messaging are still few. The most notable entrants at present are?Snapchat and Facebook’s Poke, the former which is primarily focused on sharing photos and video, and the latter which has so far failed to find significant traction. Unlike Snapchat, which leads this narrower niche, Blink allows users to send both text and photos, and supports messaging to groups, which actually makes it more like Poke. “Our main goal is to bring real world conversations online,” explains?Stephens of the new application. “The things we say in person are not written in ink, but the Internet is. We want to bring that to a mobile medium,” he adds. Stephens also notes that the youngest mobile demographic – teenagers – seem to be exhibiting more concerns over privacy. As a group that has grown up in a world where the web has always existed, where everyone uses Facebook, and are now adopting smartphones in large numbers (a recent report found that 48 percent of mobile teens own an iPhone today, for instance), it’s no wonder that they’ve been drawn to tools where their passing thoughts aren’t forever etched in stone. And though he didn’t explicitly say so, that group may be somewhat distrustful of allowing Facebook to be the steward for their most private messages, given that company’s vision and push for more openness, as opposed to less. Ephemeral messaging is

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Is Lithium Orotate safe to use for mood disorders? | BEST MEDICAL ...

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Source: http://bestmedicaltips.info/is-lithium-orotate-safe-to-use-for-mood-disorders/

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Friday, April 26, 2013

Canada terror suspect grew more radical

TORONTO (AP) ? One of two men accused of plotting with al-Qaida members in Iran to derail a train in Canada became radicalized to the point that his father reached out to a Muslim support group for help and advice, a local religious leader said Wednesday.

Muhammad Robert Heft, president of the Paradise Forever Support Group Inc., a non-profit organization that provides support to Muslims in Canada, said Mohammad Jaser came to him several times citing concerns about the radicalization of his son.

"He came to me about his son saying he how concerned he was getting about the rigidness of his son and his interpretation of Islam. He was becoming self-righteous, becoming pushy, pushing his views on how much they (his family) should be practicing as a Muslim," said Heft.

Jaser's son, Raed, 35, has been charged along with Chiheb Esseghaier, 30 with conspiring to carry out an attack and murder people in association with a terrorist group in their plot to derail a train that runs between New York City and Montreal.

Canadian investigators say the men received guidance from members of al-Qaida in Iran. Iranian government officials have said the government had nothing to do with the plot.

"His son was becoming overzealous and intolerant in his understanding of the religion," Heft said. "Those are the telltale signs that can lead into the radicalization process."

The discussions took place between 2010 and 2011, while the father was renting a basement apartment in Heft's home in Markham, Ontario.

On Wednesday, the other suspect appeared briefly in court where he made a statement suggesting he did not recognize the court's jurisdiction.

"This criminal code is not a holy book," Esseghaier said at the hearing. "We cannot rely on the conclusions taken out from these judgments."

At the hearing Esseghaier rejected the allegations against him and declined to be represented by a court-appointed lawyer.

Jaser had appeared in court Tuesday and did not enter a plea. The court granted a request by his lawyer, John Norris, for a publication ban on future evidence and testimony.

Both men were ordered to return to court on May 23.

"We are waiting for the disclosure and we will be defending against the charges," Norris said in a telephone interview on Wednesday.

Norris declined to comment when asked if he wanted his client's case separated from Esseghaier, who has spoken out twice in court despite being advised not to.

Police ? tipped off by an imam worried by the behavior of one of the suspects ? said it was the first known attack planned by al-Qaida in Canada. The two could be sentenced to life in prison if convicted.

The case has raised questions about the extent of Shiite-led Iran's relationship with al-Qaida, a predominantly Sunni Arab terrorist network. It also renewed attention on Iran's complicated history with the terror group, which ranges from outright hostility to alliances of convenience and even overtures by Tehran to assist Washington after the Sept. 11, 2001, attacks on the United States. Canadian police said this week they didn't think it was a case of state sponsored terrorism.

Law officials in New York with knowledge of the investigation told The Associated Press the attack was to take place on the Canadian side of the border. They are not authorized to discuss the investigation and spoke only on condition of anonymity.

Norris has questioned the timing of the arrests, pointing to ongoing debates in the Canadian Parliament over a new anti-terrorism law that would expand the powers of police and intelligence agencies.

Norris has noted Jaser was a permanent resident of Canada who has lived there for 20 years. Norris refused to say where Jaser was from, saying that revealing his nationality in the current climate amounted to demonizing him.

Canadian police have declined to release the men's nationalities, saying only they had been in Canada a "significant amount of time." But a London-based newspaper Al Arab reported Wednesday, citing unnamed sources in the Gulf, that Jaser is a Jordanian passport holder with full name Raed Jaser Ibrahim Amouri, who had visited the UAE several times and most recently in September 2011. The newspaper reported that the suspect also visited other Gulf countries including Qatar and Saudi Arabia. It was not possible to independently confirm the report.

Esseghaier, in a profile on a university department website ? which has since been removed ? says he was born in Tunis, Tunisia.

The investigation surrounding the planned attack was part of a cross-border operation involving Canadian law enforcement agencies, the FBI and the U.S. Department of Homeland Security. Canadian police said the men never got close to carrying out the attack.

The warning first came from an imam in Toronto, who in turn was tipped off by suspicious behavior on the part of one of the suspect.

___

Associated Press writers Benjamin Shingler in Montreal, Tom Hays in New York, Kimberly Dozier in Washington and Brian Murphy in the United Arab Emirates contributed to this story.

Source: http://news.yahoo.com/canada-terror-suspect-grew-more-radical-211749852.html

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Ecology buys time for evolution: Climate change disrupts songbird's timing without impacting population size (yet)

Apr. 25, 2013 ? Songbird populations can handle far more disrupting climate change than expected. Density-dependent processes are buying them time for their battle. But without (slow) evolutionary rescue it will not save them in the end, says an international team of scientists led by the Netherlands Institute of Ecology (NIOO-KNAW) in Science this week.

Yes, spring started late this year in North-western Europe. But the general trend of the four last decades is still a rapidly advancing spring. The seasonal timing of trees and insects advance too, but songbirds like Parus major, or the great tit, lag behind. Yet without an accompanying decline in population numbers, it seems, as the international research team shows for the great tit population in the Dutch National Park the Hoge Veluwe.

"It's a real paradox," explain Dr Tom Reed and Prof Marcel Visser of the Netherlands Institute of Ecology. "Due to the changing climate of the past decades the egg laying dates of Parus major have become increasingly mismatched with the timing of the main food source for its chicks: caterpillars. The seasonal timing of the food peak has advanced over twice as fast as that of the birds and the reproductive output is reduced. Still, the population numbers do not go down." On the short term, that is, as Reed, Visser and colleagues from Norway, the USA, and France have now calculated using almost 40 years of data from this songbird.

The solution to the paradox is that although fewer offspring now fledge due to food shortage, each of these chicks has a higher chance of survival until the next breeding season. "We call this relaxed competition, as there are fewer fledglings to compete with," first author Reed points out. Out of 10 eggs laid, 9 chicks are born, 7 fledge and on average only one chick survives winter. That last number increases with less competitors around.

This is the first time that density dependence -- a widespread phenomenon in nature -- and ecological mismatch are linked, and it is a real eye-opener. Reed: "It all seems so obvious once you've calculated this, but people were almost sure that mistiming would lead to a direct population decline."

The great tits that lay eggs earlier in spring are more successful nowadays than late birds, which produce relatively few surviving offspring. This leads to increasing selection for birds to reproduce early. But the total number of birds in the new generation stays the same. "That is the second paradox," the researchers state. "Why are population numbers hardly affected, despite the stronger selection on timing caused by the mismatch? The answer is that for selection it matters which birds survive, while for population size it only matters how many survive. Visser: "The mortality in one group can be compensated for by the success in another. But this stretching, this flexibility, is not unlimited."

The mismatch between egg laying period and caterpillar peak in the woods will keep growing, and so will the impact following the temporary rescue, as long as spring temperatures continue to increase. "The density dependence is only buying the birds time, hopefully for evolutionary adaptation to dig in before population numbers are substantially affected," according to Visser. The new findings can help to predict the impact of future environmental change on other wild populations and to identify relevant measures to take. Even rubber bands stretch only so far before they break.

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The above story is reprinted from materials provided by Netherlands Institute of Ecology (NIOO-KNAW), via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


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Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/uKfjHEgIXbM/130425142348.htm

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Ukky iPhone app journals your child's life, gives your Facebook followers a break

Ukky iPhone app journals your child's life, gives your Facebook followers a break

Look, we've all been there -- that moment when palm meets face after viewing the umpteenth image of your best friend's child. As cute as Louie is, there's a finite quantity of JPEGs that one can stand if you aren't Louie's creator. Of course, scaling back the number of offspring photos uploaded to public social networks wasn't the intention of those who crafted Ukky, but it's a side effect that the childless among us will no doubt appreciate. Showcased this week at The Next Web Conference, Ukky is a (gorgeous) iPhone app that's designed to journal the life of your youngster, and your interactions along the way. The word itself is Dutch for "little one" (or so I'm told), and it effectively brings the world of Path to a different niche.

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Source: http://www.engadget.com/2013/04/25/ukky-iphone-app-journals-child-life-demo/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Nasal lining used to breach blood/brain barrier

Apr. 24, 2013 ? Neurodegenerative and central nervous system (CNS) diseases represent a major public health issue affecting at least 20 million children and adults in the United States alone. Multiple drugs exist to treat and potentially cure these debilitating diseases, but 98 percent of all potential pharmaceutical agents are prevented from reaching the CNS directly due to the blood-brain barrier.

Using mucosa, or the lining of the nose, researchers in the department of Otology and Laryngology at the Massachusetts Eye and Ear/Harvard Medical School and the Biomedical Engineering Department of Boston University have demonstrated what may be the first known method to permanently bypass the blood-brain barrier, thus opening the door to new treatment options for those with neurodegenerative and CNS disease. Their study is published on PLOS ONE.

Many attempts have been made to deliver drugs across the blood-brain barrier using methods such as osmotic disruption and implantation of catheters into the brain, however these methods are temporary and prone to infection and dislodgement.

"As an endoscopic skull base surgeon, I and many other researchers have helped to develop methods to reconstruct large defects between the nose and brain using the patient's own mucosa or nasal lining," said Benjamin S. Bleier, M.D., Otolaryngologist at Mass. Eye and Ear and HMS Assistant Professor.

Study co-author Xue Han, Ph.D., an assistant professor of Biomedical Engineering at Boston University, said, "The development of this model enables us to perform critical preclinical testing of novel therapies for neurological and psychiatric diseases."

Inspired by recent advances in human endoscopic transnasal skull based surgical techniques, the investigators went to work to develop an animal model of this technique and use it to evaluate transmucosal permeability for the purpose of direct drug delivery to the brain.

In this study using a mouse model, researchers describe a novel method of creating a semi-permeable window in the blood-brain barrier using purely autologous tissues to allow for higher molecular weight drug delivery to the CNS. They demonstrated for the first time that these membranes are capable of delivering molecules to the brain which are up to 1,000-times larger than those excluded by the blood-brain barrier.

"Since this is a proven surgical technique which is known to be safe and well tolerated, this data suggests that these membranes may represent the first known method to permanently bypass the blood-brain barrier using the patient's own tissue," Dr. Bleier said. "This method may open the door for the development of a variety of new therapies for neurodegenerative and CNS disease.

Future studies will be directed towards developing clinical trials to test this method in patients who have already undergone these endoscopic surgeries."

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The above story is reprinted from materials provided by Massachusetts Eye and Ear Infirmary.

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Journal Reference:

  1. Benjamin S. Bleier, Richie E. Kohman, Rachel E. Feldman, Shreshtha Ramanlal, Xue Han. Permeabilization of the Blood-Brain Barrier via Mucosal Engrafting: Implications for Drug Delivery to the Brain. PLoS ONE, 2013; 8 (4): e61694 DOI: 10.1371/journal.pone.0061694

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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/gkF2Z1R2mSc/130424185207.htm

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